INFECTIOUS AGENTS AS MODIFYING FACTORS OF DE NOVO HORMONE SYNTHESIS IN TUMOR TISSUE IN PATIENTS WITH UTERINE CARCINOMA

DOI: https://doi.org/None

V.A. Bandovkina, E.M. Frantsiyants, T.I. Moiseenko, M.A. Vovkochina, M.L. Adamyan, E.F. Komarova, N.D. Cheryarina, T.A. Zykova Rostov Research Institute of Oncology, 14 Line, 63, Rostov-on-Don, 344037, Russian Federation

Introduction. The influence of widespread, often long-lasting infections like herpes simplex virus (HSV), cytomegalovirus (CMV) and chlamydia infections on endocrine profile in organs of reproductive system and the role of infections in pathogenesis of uterine carcinoma are poorly studied. The purpose of the study was to analyze the effect of single and combined infectious agents on local hormonogenesis of uterine tissues in menopausal patients with uterine carcinoma. The aim of the study. Study of the effect of single and combined infectious agents on the local hormonogenesis of endometrium in hysterocarcinoma patients in menopausa. Methods. Levels of sex hormones, estrogen metabolites, sex hormone-binding globulin (SHBG), prolactin and E6 oncoprotein were detected by the ELISA method in 82 samples of endometrial tissue from hysterocarcinoma patients (T1-2N0M0). HPV DNAs were processed by the multiplex PCR method. Results. Single and/or combined infections in tumor tissue resulted in the increase of levels of estrone by 1,3–1,7 times, estradiol – by 1,6–1,9 times, prolactin – by 3 times and decrease of testosterone level by 1,4–3,4 times. Conclusion. The presence of infectious agents has modifying effect on local hormonogenesis in terms of the gain in the intensity of disorders which leads to the imbalance of steroids, adverse changes in the ratio of estrogen metabolites and the increase of prolactinemia not only in tumor tissue but in intact ovaries in patients with uterine carcinoma as well.
Keywords: 
uterine carcinoma, viruses, chlamydias, sex hormones, prolactin, sex hormone-binding globulin, E6 oncoprotein
Список литературы: 
  1. Ness R.B., Goodman M.T. Shen C. et al. Serologic evidence of pastinfection with Chlamydia trachomatis, in relation to ovarian cancer. J. Infect. Dis. 2003; 187 (7): 1147–52.
  2. Ashrafyan L.A., Kiselev V.I. Opuholi reproduktivnyh organov (e`tiologiya i patogenez). M.: Dimitreyd Grafik Grupp, 2007. [Ashrafjan L.A., Kiselev V.I.. Opuholi reproduktivnyh organov (jetiologija i patogenez). M.: DimitrejdGrafikGrupp, 2007 (in Russian)]
  3. Sidorova I.S. Mioma matki Ambulatorno poliklinicheskaya pomoshh` v akusherstve i ginekologii (prakticheskoe rukovodstvo dlya vrachey). M.: MEDpress-inform, 2007; 475–529. [Sidorova I.S. Mioma matki Ambulatorno poliklinicheskaja pomoshh’ v akusherstve I ginekologii (prakticheskoe rukovodstvo dlja vrachej). M.: MEDpress-inform, 2007; 475–529 (in Russian)]
  4. Kiselev V.I., Sidorova I.S., Unanyan A.L., Muzheynek E.L. Giperplasticheskie processy organov zhenskoy reproduktivnoy sistemy: teoriya i praktika. M.: Medpraktika, 2011.[Kiselev V.I., Sidorova I.S., Unanjan A.L., Muzhejnek E.L. Giperplasticheskieprocessyorganovzhenskoj reproduktivnojsistemy: teorijaipraktika. M.: Medpraktika, 2011 (in Russian)]
  5. Rosner W., Hryb D.J., Khan M.S. Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane. J. Steroid Biochem. Mol. Biol. 2010; 69 (1–6): 481–5.
  6. Franciyanc E.M., Bandovkina V.A., Gus`kova N.K., Komarova E.F. Vliyanie voshodyashhey hlamidiynoy infekcii na uroven` polovyh gormonov v krovi u zhenshhin s vospalitel`nymi i proliferativnymi processami genitaliy. Fundamental`nye issledovaniya. 2013; 7 (2): 419–22.[Francijanc E.M., Bandovkina V.A., Gus’kova N.K., Komarova E.F. Vlijanie voshodjashhej hlamidijnoj infekcii na uroven’ polovyh gormonov v krovi u zhenshhin s vospalitel’nymi i proliferativnymi processami genitalij. Fundamental’nye issledovanija 2013; 7 (2): 419–22 (in Russian)]
  7. Babaeva N.A., Ashrafyan L.A., Antonova I.B., Lyustik A.V. Rol` papillomavirusnoy infekcii pri rake zhenskoy reproduktivnoy sistemy v postmenopauzal`nom periode. Vestnik rossiyskogo nauchnogo centra rentgenoradiologii. 2013 (URL: http:// vestnik.rncrr.ru).[Babaeva N.A., Ashrafjan L.A., Antonova I.B., Ljustik A.V. Rol’ papillomavirusnoj infekcii pri rake zhenskoj reproduktivnoj sistemy v postmenopauzal’nom periode. Vestnikrossijskogo nauchnogocentra rentgenoradiologii. 2013 (URL: http:// vestnik.rncrr.ru) (in Russian)]