TRANSLATIONAL AND POST-TRANSLATIONALREGULATION OF ACTIVITY OF HIF-1 IN HYPOXIA AND ISCHEMIA

DOI: https://doi.org/None

V.A. Ruzaeva, E.B. Boitsova, A.B. Salmina Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Partizana Zheleznyaka str., 1, Krasnoyarsk, 660022, Russian Federation

This review covers current concepts on the structure, function, regulation of translation and post-translational modifications of hypoxiainducible factor 1 (HIF-1). In addition, the role of this transcription factor in hypoxia and ischemia is discussed. We focus on using HIF-1 as a molecular target for new pharmacological therapeutic strategies in wide spectrum of diseases associated with alterations in energy metabolism.
Keywords: 
hypoxia-inducible factor 1 (HIF-1), transcriptional factors, translation, post-translational modification, hypoxic-ischemic injury
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