MOLECULAR GENETIC MARKERS IN EVALUATING RISK OF OCCUPATIONAL DISEASES AMONG WORKERS IN THE CHEMICAL PRODUCTIONS

DOI: https://doi.org/None

G.F. Mukhammadiyeva, A.B. Bakirov, D.O. Karimov, E.G. Bagautdinova, L.K. Karimova, E.T. Valeyeva Ufa Research Institute of Occupational Health and Human Ecology, Stepana Kuvykina Str., 94, Ufa, 450106, Russian Federation

Introduction. Determination of the role of genetic markers in the formation of individual susceptibility to the effects of harmful chemicals both opens up new possibilities for assessing the risk of occupational and production-related diseases and address prevention. This area includes the study of the genes responsible for the biotransformation of xenobiotics and cell cycle control. The aim of the study. Analysis of the association of polymorphic variants of genes of xenobiotic biotransformation enzymes (cytochrome P450 (CYP1A1, CYP2E1), glutathione S-transferase (GSTM1, GSTT1, GSTP1)) and tumor suppressor gene TP53 at risk for personal nosological forms of occupational diseases among workers of various chemical industries. Methods. Polymerase chain reaction with the determination of restriction fragment length polymorphism. Results. The genotype Val/Val GSTP1 gene was found to be a marker of resistance to the action of hepatotropic poisons. The C allele of the TP53 Ex4 + 119G> C polymorphism, the 16bp allele of the TP53 IVS3 16 bp Del/Ins and the A allele of the TP53 IVS6 + 62A> G are associated with an increased risk of occupational skin neoplasms Conclusion. The results suggest the possible use of molecular genetic indices to assess the personal risk of the increased development and prognosis of occupational diseases induced by exposure to chemical factors of production and the development of preventive measures.
Keywords: 
occupational diseases, genes, enzymes of biotransformation of xenobiotics, gene TP53, risk assessment, harmful production factors
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