L.Yu. Grivtsova N.N. Blokhin Russian Cancer Research Center, Kashirskoye shosse, 24, Moscow, 115478, Russian Federation

Introduction. Currently there was described a number of subpopulations of haematopoietic stem cells and progenitor cells, important for completeness of the recovery of hematopoiesis and antigens involved in the process of homing, adhesion and mobilization of haematopoietic stem cells. The aim of the study. Characteristics of the subpopulation composition of haematopoietic stem cells and progenitor cells based on membrane immunophenotype to predict the completeness of recovery of hematopoiesis, and the evaluation of the kinetics of mobilization of peripheral blood hematopoietic stem cells. Metods. Subpopulation content of mobilized peripheral blood hematopoietic stem cells (PBHSC) has been studied in 347 patients with oncohaematological malignancies (158 adult and 189 children) and 54 adult donors of allogeneic PBHSC. Results. There is more pronounced effect of mobilization (total number of CD34+ cells) detected in adult patients with multiple myeloma (MM), in children with Ewing's Sarcoma and neuroblastoma, as well as in healthy donors. Relatively to the subpopulation, the effect of mobilization was more pronounced in healthy individuals and children with medulloblastoma and neuroblastoma. Conclusion. According to immunological criteria (CD34+CD38–HLA-DR–Thy-1+) the most completed haematopoiesis recovery takes place after transplantation of donors PBHSCs in adults with Hodgkins lymphoma, children with PNEO, medulloblastoma and neuroblastoma.
peripheral mobilized hematopoietic stem cells (HSC), subpopulations, oncohaematology, transplantation

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