PEPTIDE SEQUENCES MIMICKING THE EXTRACELLULAR MATRIX AS A PROMISING OPTION FOR BIOFUNCTIONALIZATION OF CARDIOVASCULAR GRAFTS

DOI: https://doi.org/None

V.G. Matveeva, L.V. Antonova, O.L. Barbarash, L.S. Barbarash Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd., 6, Kemerovo, 650002, Russian Federation

Early endothelialization of the inner surface of cardiovascular grafts is imperative for achieving successful functioning in the body. Biofunctionalization of synthetic materials allows to create biomimetic surfaces by incorporating bioactive molecules capable of promoting specific cell responses. This review focuses on problems and prospects in the synthesis of various types of peptide sequences, mimicking the structure and function of the extracellular matrix, for fast and directed attraction of endothelial cells to synthetic surfaces. Particular attention is paid to the methods of peptide immobilization onto polymer surfaces, allowing to keep their bioactive properties. Biofunctionalization of synthetic materials for early endothelialization in situ with the use of peptide sequences is a promising approach for the development of cardiovascular grafts.
Keywords: 
biofunctionalization of materials, peptide sequence, endothelialization, cardiovascular grafts
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