LEPTIN AND ITS ROLE IN THE DEVELOPMENT OF THE FETUS AND NEWBORN INFANT

DOI: https://doi.org/10.29296/24999490-2018-01-02

I.I. Evsyukova, E.K. Aylamazyan D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya line, 3, Saint-Petersburg, Russian Federation, 199034 E-mail: [email protected]

The review presents results of clinical and experimental investigations, revealed leptin’s role in the mechanisms of morphological and physiological development of the fetus and newborn. This review summarizes many of the published reports about the leptin’s role in morphological and functional development of placenta, fetus and newborn infant. The results of clinical and experimental investigations testify to the participation of leptin in the mechanisms of the formation of placenta, it’s autocrine and endocrine processes, in the regulation of growth the gristly cartilaginous and bone’s tissues of fetus, in the development of his lung, maturation of the adipose tissue, stimulation of fetal erythroid and myeloid development, in the regulation of nutrients food intake and energy homeostasis. The influences of leptin on proliferation, differentiation neurons and development of the neuronal excitability, cognitive and memory. Hormone regulates in CNS production and secretion of neuropeptides for controlling appetite and energy balance. The leptin’s role is demonstrated in the survival, postnatal adaptation and the subsequent development of infant’s functional systems in normal and pathological conditions.
Keywords: 
leptin, placenta, fetus, newborn
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