GENETICS OF PRIMARY HEADACHES (LITERATURE REVIEW)

DOI: https://doi.org/10.29296/24999490-2018-02-03

A.V. Kondratyev(1), N.A. Shnayder(1, 2), A.V. Shulmin(2), A.I. Lomakin(1) 1-Clinical Hospital №51 of the Federal Medical-Biological Agency of Russia, Kirova str., 5, Zheleznogorsk, Russian Federation, 662971; 2-V.F.Voyno-Yasenetsky Krasnoyarsk State Medical University, Partizana Zheleznyaka str., 1, Krasnoyarsk, Russian Federation, 660022 E-mail: [email protected]

The headache is an important medical and social problem. Currently, genetics is the least-studied component of the pathogenesis of primary headaches. The most common forms of primary headache include migraine, tension type headache, cluster headache. This article represents the overview of domestic and foreign literature on the genetics of these forms of headache. Primary headaches are polygenic multifactorial diseases, pathogenesis of which is combined interaction between multiple susceptibility genes and environmental factors. The most frequently mentioned in the literature MTHFR, TRPV, CGRP, HCRTR genes, are associated with the risk of primary headaches. However, given data are heterogeneous and contradictory in the literature, many studies of genetic markers headaches are false positives or not reproducible in other studies. This indicates to a lack of knowledge of the genetics of headaches and confirms the relevance of research in this area. Knowledge of genetic characteristics will improve the treatment and prevention of headaches from the standpoint of personalized medicine
Keywords: 
headache, gene, genetics, single nucleotide polymorphism, locus, personalized medicine

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