«RISKY» COMBINATIONS OF CANDIDATE GENES FOR HYPERPLASTIC PROCESSES OF THE ENDOMETRIUM

DOI: https://doi.org/10.29296/24999490-2018-02-09

I.V. Ponomarenko(1), K.I. Prashchayeu(2, 3), G.G. Shaginyan(2), M.I. Churnosov(1), A.N. Ilnitski(2, 3), E.V. Khrokhmaliova(2) 1-Belgorod National Research University, Pobedy str., 85, Belgorod, 308015, Russian Federation; 2-Research medical center «Gerontology», Aeroportovskaya str., bld. 4, Moscow, 125319, Russian Federation; 3-The Postgraduate Institute of Federal Medico-Biological Agency, Volokolamskoe av., 91, Moscow, Russian Federation, 125371 E-mail: [email protected]

Introduction. Endometrial hyperplasia represents a chronic progressive disease characterized by high prevalence among women in older age groups. The aim of the study. To study the involvement of combinations of candidate genes in the formation of hyperplastic processes of the endometrium. Methods. The sample for the study was 1501 person: 520 patients with endometrial hyperplasia and 981 female control group. Molecular genetic analysis of 4 loci was performed by polymerase chain reaction of DNA synthesis using standard oligonucleotide primers and probes. Analysis of the role of combinations of candidate genes in the occurrence of hyperplastic processes of the endometrium was performed using software APSampler using Monte Carlo Markov chains and Bayesian nonparametric statistics. Results. It was found that among women in the Central region of Russia risk factors for the development of endometrial hyperplastic processes are combinations of molecular genetic markers rs1398217 G, G rs887912, G rs2090409 (OR=1,32) and G rs1398217 c T rs10441737 and G rs2090409 (OR=1,30). Conclusion. The results indicate a significant role of the studied candidate genes in the development of hyperplastic processes of the endometrium.
Keywords: 
endometrial hyperplasia, genetic polymorphism
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