PERSONALIZED MEDICINE: FROM IDEA TO IMPLEMENTATION IN PRACTICAL HEALTH CARE

DOI: https://doi.org/10.29296/24999490-2018-03-02

N.N. Belushkina(1), A.S. Chemezov(2), M.A. Paltsev(1, 2) 1-N. M. Emanuel Institute of Biochemical Physics, 4, Kosygina str., Moscow, 119334, Russian Federation 2-Moscow State University. M.V. Lomonosov Moscow, 119991, Russian Federation, Moscow, Leninskie gory, 1 E-mail: [email protected]

The review considers the main trends of the new concept of individual health medicine, called the predictive preventive personalized participative medicine – P4 Medicine. Medico-biological and medico-social prerequisites for the development of personalized medicine, the main tasks and approaches to the implementation of P4 Medicine are considered. Personalized medicine is based on scientific and technological and methodological achievements in the field of genomics, transcriptomics, proteomics, metabolomics, and bioinformatics. The review presents modern molecular methods and technologies actively used in P4 Medicine, including blockchain technologies and artificial intelligence. The solution of problems of personalized medicine is considered on the example of oncological and autoimmune diseases, the algorithms of therapy at preclinical and clinical stages of diseases are shown to take into account the individual genetic and pathogenetic status of the patient. The main tasks of promoting the concept of personalized medicine into practical health care and the main constraints of introducing the principles of personalized medicine into clinical practice are considered. P4 Medicine, as a new direction of medicine, focused on individual health, is potent both of really stabilizing the incidence rates and reducingthe disability rate of the able-bodied population, significantly decline traditionally high costs of treating ill people.
Keywords: 
personalized medicine, P4 Medicine, blockchain technologies, omics-technologies, artificial intelligence
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