ASSOCIATION OF GENETIC MARKERS WITH THE DEVELOPMENT OF ENDOCARDITIS OF NONINFECTIOUS AND INFECTIOUS ETIOLOGY

DOI: https://doi.org/10.29296/24999490-2018-06-09

Yu.S. Bakhareva(1), V.N. Maksimov(1, 2), A.A. Ivanova(1), N.N. Chapaeva(2) 1-Scientific-research Institute of Therapy and Preventive Medicine – the branch of the Federal Research Center Institute of Cytology and Genetics, B. Bogatkova str., 175/1, Novosibirsk, 630089, Russian Federation; 2-Novosibirsk State Medical University, Krasny Prospekt, 52, Novosibirsk, 630091, Russian Federation E-mail: [email protected]

Introduction. New technologies of DNA genotyping and sequencing contribute to the rapid accumulation of our knowledge about human genomic variations and search for inherited determinants of complex genetic traits. There is a large amount of data on associations of single nucleotide polymorphisms in the genes of the hemostatic system and folate cycle with the development of cardiovascular diseases. Objective: to identify possible associative links between polymorphisms of candidate genes and the development of endocarditis of infectious and noninfectious genesis. Results. 175 examined patients were divided into two groups: the first included 81 non – infectious endocarditis patient and the second -94 infectious endocarditis cases. There was found an association between endocarditis and rs1126643 (759 C>T) of ITGA2 gene and rs1805087 (2756A>G) of MTR gene. Conclusion. We present a comparative analysis of genotype frequencies of polymorphisms of the twelve genes of the hemostatic system and the folate cycle. For two of the twelve polymorphisms studied by ourselves, an association with vegetations on the valve apparatus of the heart was revealed.
Keywords: 
noninfectious and infectious endocarditis, single-nucleotide polymorphism hemostasis
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