ANALYSIS OF POLYMORPHISM OF GENES OF THE HEMOSTASIS SYSTEM IN PREGNANT WOMEN SUFFERING A MIGRAINE

DOI: https://doi.org/10.29296/24999490-2019-03-05

B.A. Bakirov(1), Kh.P. Derevyanko(1), D.A. Kudlay(2) 1-Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Healthcare of the Russian Federation, ul. Lenina, 3, Ufa, 450008, Russian Federation; 2-NRC Institute of Immunology FMBA of Russia, Kashirskoye highway, 24, Moscow, 115522, Russian Federation E-mail: [email protected]

Introduction. The study of the genetic mechanisms of migraines is based on the investigation of genes of possible susceptibility and analysis of the influence of gene polymorphism in combination with environmental factors that form the pathogenetic chain of the disease. Purpose of the study. Evaluation of the polymorphism of the hemostatic system genes in women with migraine attacks during pregnancy. Methods. The examination of 94 women during pregnancy with a migraine history was performed at the Department of Pregnancy Pathology at the Clinic of Bashkir State Medical University. The diagnosis of migraine was made according to the diagnostic criteria of the International Society for the Study of Headache. The was examination of hemostasis of patients: FGB: – 455, F2:20210, F5: 1691, F7: 10976, F13, PAI-1:-675, ITGB3:-1565, MTHFR:677. Results. MTHFR allele carriers: 677 T were detected in 47,2% of patients with migraine and 7,7% among the control group (p=0,01). Among patients with migraine, carriers of the 1565C allele in the ITGB3 gene were more common (13,3 versus 11,3% in the control group, p=0,08). In the group of patients with migraine the increase in the frequency of occurrence of the homozygous genotype of fibrinogen FGB: -455 AA compared with the control group was observed: 12,5 versus 10,8% ,respectively (p> 0.05). Conclusion. Understanding of genetically determined thrombophilic states will help in an interdisciplinary approach in genodiagnostics and personalized prevention of the pathology of hemostasis in case of migraines during pregnancy.
Keywords: 
migraine, pregnancy, genetic polymorphism
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