P.K. Yablonsky(1), V.O. Polyakova(1, 2), Yu.S. Krylova(1, 4), A.O. Drobintseva(1, 3), D.O. Leonteva1, E.G. Sokolovich(1), I.M. Kvetnoy(1, 2) 1-Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, Ligovskij avenue, 2–4, Saint-Petersburg, 191036, Russian Federation; 2-Saint-Petersburg University, Universitetskaya Embankment, 7–9, Saint-Petersburg, 199034, Russian Federation; 3-St. Petersburg State Pediatric Medical University, Litovskaya street, 2, Saint-Petersburg, 194100, Russian Federation; 4-Pavlov First Saint Petersburg State Medical University, Street L’va Tolstogo, 6–8, Saint-Petersburg, 197022, Russian Federation E-mail: [email protected]

Introduction. Sarcoidosis is a systemic granulomatous disease of unknown etiology, which leads to disruption of the human respiratory system and can lead to damage to other systems. In clinical practice, doctors often run into difficulties in differentiating sarcoidosis from tuberculosis – another granulomatous disease, because of their similar clinical and radiological pictures. None of the existing methods for diagnosing sarcoidosis or tuberculosis is absolute. However, the correct and timely diagnosis plays an important role in the successful treatment of these pulmonary pathologies. The aim of the study. Determination of the neuro-immuno-endocrine profile of sarcoid granuloma. Methods. Namely, proteins were studied: interleukin-8 (IL8), Protein gene product 9.5 (PGP9.5), tissue inhibitor of metalloproteinases (TIMP1), melatonin receptor 1A (RM-1A), melatonin receptor 1B (RM-1B). Results. Studies have shown sarcoid granulomas to express IL-8 with the presence of nerve – PGP9.5 positive terminals in peri-granuloma tissue, thus labeling granuloma, we suggest IL-8 be able to become a diagnostic marker of lung sarcoidosis. The data on the expression of TIMP1, RM-1A, and RM-2B are ambiguous and require further study. Conclusion. Thus, the neuro-immuno-endocrine aspects of granulomatous inflammation are interesting for further research at various stages of sarcoidosis, as well as for tuberculosis.
рulmonary sarcoidosis, granulomatous inflammation, sarcoid granuloma, IL-8, neuroimmunoendocrine interactions

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