PROTECTIVE IMPACT OF BIOREGULATOR PEPTIDES BY EFFECT OF CONSTANT GEOMAGNETIC FIELD ON ORGANOTYPIC TISSUE CULTURE OF VARIOUS GENESIS

DOI: https://doi.org/10.29296/24999490-2020-02-09

N.I. Chalisova(1, 2), A.V. Rubinskii(3), T.D. Vlasov(3), 1-Pavlov Institute of Physiology, St. Petersburg, Nab. Makarova 6, 199034, Russian Federation; 2-St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, pr. Dinamo 3, 197110, Russian Federation; 3-Pavlov First State Medical Institute, St. Petersburg, L. Tolstoy street, 6–8, 197022, Russian Federation E-mail: [email protected]

Introduction. The investigations of the magnetic-biological effects are actual because the modern technical works are related to the constant magnetic field (CGF) Purpose of the study was the investigation of impact of (CMF) on the tissues of various genesis – ecto-, meso- and entodermal. Method of organotypic culture of tissues of Wistar line rats was used. Results. CMF with 200 mTl induction had no effect on the tissues of meso- and entodermal genesis (liver, kidney, prostate gland, myocardium). However CMF inhibited CMF cell proliferation in the nervous tissue of brain cortex and in the spleen immune tissue. The introduction in the cultural media of bioregulator peptides MNN-1 and MNN-2 delated the inhibitory CMF effect and the cell proliferation was as in the control explants. Conclusion. The data obtained the protective effect of bioregulator can be used for the normalization of the proliferation potential of tissues, and also for the elaboration of the scientific recommendations for the reglament norms by exploitation of magnetic-levitation transport systems and for the passenger and workers protection from the technogenic effect
Keywords: 
organotypic culture tissue, bioregulator peptides
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