β2 MICROGLOBULIN AND THE AGING PROCESS

DOI: https://doi.org/10.29296/24999490-2020-04-04

B.I. Kuznik(1, 2), N.I. Chalisova(3, 4) 1-Chita State Medical Academy, Babushkina str., 46, Chita, 672090, Russian Federation; 2-Innovation Clinic of the Academy of Health, Kokhanskogo str., 13, Chita, 672000, Russian Federation; 3-Pavlov Institute of Physiology, nab. Makarova, 6, Saint Petersburg, 199034, Russian Federation; 4-Saint Petersburg Institute of Bioregulation and Gerontology, Dinamo pr., 3, Saint Petersburg, 197110, Russian Federation Е-mail: ni_chalisova@ mail.ru

The problems of longevity increase and its quality improvement are actual for the modern gerontology. So far it is necessary to complete tasks of early diagnostic and target prophylactic of the age-associated pathology. There are presented the data concerning β2-microglobulin (β2М), one of the frequent marker of aging. There are considered the data about the structure, properties, and functions of β2М, in which concentration is increased by aging. The experiments demonstrated the β2М concentration to increase in the hippocampus of old animals as in young heterochronic parabionts. The great correlation is observed between the β2М concentration and the deterioration of cognitive functions as well as the development of dementia. β2М plays a great role in the development of cardiovascular disease. The heart ischemic disease, the pathology of arteria carotis and peripheral vessels were more expressive in the patients with a great β2М concentration in plasma. It was the correlation between diabetes mellitus severity and high β2М level. β2М, as an oncogenic factor, stimulates the development and metastasis of the different cancers. The determination of plasma β2М concentration is of great significance for the predictive medicine and the prophylactic of the age-associated pathology.
Keywords: 
β2-microglobulin, aging, cognitive functions, dementia, cardiovascular diseases, diabetes, cancer

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