PROTECTIVE EFFECT OF BIOREGULATORY PEPTIDES ON THE ORGANOTYPIC TISSUE CULTURE DEVELOPMENT IN CYTOSTATIC PRESENCE

DOI: https://doi.org/10.29296/24999490-2020-06-08

G.A. Rizhak(1), N.I. Chalisova1, 2, E.S. Zalomaeva(1, 2), O.M. Ivko(1), P.N. Ivanova(1, 2) 1-St.Petersburg Institute of Bioregulation and Gerontology, Dinamo pr., 3, St. Petersburg, 197110, Russian Federation; 2-Pavlov Institute of Physiology, nab. Makarova 6, St. Petersburg, 199034, Russian Federation E-mail: [email protected]

Introduction. The delay of the adverse events by the use of drugs is an actual medicine task. The cytostatics inhibiting cellular proliferation, are using in a clinic for the hindering tumor development. Thus, the adverse events occur due to the damage of healthy cells. Aim of the study. To investigate bioregulatory peptide effects on a decrease of cytostatic inhibition in the culture of different genesis Methods. Organotypic culturing of tissue of the brain cortex, spleen, kidney of Wistar line rats under the presence of cytostatic cyclophosphane (CP) as well the complex and synthesized peptides also were used. Results. The combined effect of complex peptide thymalin or the synthesized peptide KE cytostatic inhibiting effect on the cellular proliferation in the tissues of different genesis is decreased by 14–28%. Conclusion. The obtained data about the effect of bioregulatory peptides create the base for their further investigation as the drugs for the delay of adverse effects by the cytostatic therapy. These drugs can be used in clinical practice for the treatment of cancer patients, receiving cytostatic therapy.
Keywords: 
bioregulatory peptides, cytostatic, organotypic culture tissue, cellular proliferation
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