ATOPIC DERMATITIS: A MODERN VIEW OF INTERCELLULAR INTERACTIONS

DOI: https://doi.org/10.29296/24999490-2021-04-03

E.L. Iskra, A.S. Iskra, V.O. Polyakova, R.A. Nasirov Saint-Petersburg State Pediatric Medical University, Litovskay street, 2, Saint-Petersburg, 194100, Russian Federation E-mail: [email protected]

Atopic dermatitis (AD) is characterized by a violation of the epidermal barrier dysfunction. This review examines the work of the authors who describe mutations in the filaggrin gene as predisposing factors for the development of AD and describe the dysfunction of the epidermal barrier as a causal mechanism. In recent years, signaling molecules have been widely studied as a key factor in the development of a particular pathology, including signaling molecules of intercellular contacts that play an important role in the pathogenesis of AD. Claudins are the main proteins that make up dense compounds. The analyzed articles in which proteins with dense compounds of claudin-1,7, claudin-10, occludin. It determines the density of these contacts and plays an important role in providing the barrier function. Evaluation of the expression level for further correction of proteins with dense compounds may be an important therapeutic target for targeted therapy of various diseases, including AD.
Keywords: 
transmembrane protein, atopic dermatitis, claudin, dense compound, occludin
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