M.A. Paltsev(1), A.O. Drobintseva(2, 3), E.S. Mironova(2, 4), E.M. Paltseva(5), Do Ngoc Hop(2, 6, 7), U.A. Novak-Bobarykina(6), D.O. Leontyeva(2, 4)
1-Lomonosov Moscow State University, Leninskie gory, 1, Moscow, 119192, Russian Federation;
2-St. Petersburg Research Institute of Phthisiopulmonology, Ligovsky Ave., 2–4, St. Petersburg, 191036, Russian Federation;
3-St. Petersburg State Pediatric Medical University, Litovskaya st., 2, St. Petersburg, 194100, Russian Federation;
4-St. Petersburg Institute of Bioregulation and Gerontology, Dynamo Ave., 3, St. Petersburg, 197110, Russian Federation;
5-Russian Academy of Sciences, Leninsky Ave., 32a, Moscow, 119334, Russian Federation;
6-St. Petersburg State University, Universitetskaya amb., 7/9, St. Petersburg, 199034, Russian Federation;
7-Dr. Vietnam Military Medical University, Phung Hung st., 160, Hanoi, Vietnam

The pathology of the respiratory organs is the leading one in the structure of the general human morbidity. Every year the number of diseases of the respiratory system increases, and the associated mortality increases in parallel. The study of the causes and mechanisms of development of lung pathology, as well as the development of adequate methods for diagnosing, treating and preventing diseases of the respiratory system, carried out at the molecular and cellular levels, is not only an important, but also an extremely urgent task of biomedicine. As is known, the violation of homeostasis between cell proliferation and apoptosis leads to inflammatory changes and/or fibrosis of the lung tissue. The purpose of this review was to systematize scientific data on the expression of kisspeptins and their function in the pathology of the respiratory system. Material and methods. The expression of kisspeptins and their receptors was analyzed in pulmonary fibrosis, bronchial asthma, and non-small cell lung cancer. In addition, the role of kisspeptins in the development of the body’s immune response to viral infections in the cells of the ciliated epithelium of the upper respiratory tract has been shown. Conclusion. More and more data from modern studies demonstrate the involvement of kisspeptins and their participation in the regulation of the cell cycle, limiting cell metastasis, and other processes.
kisspeptins, pulmonary fibrosis, bronchial asthma, lung carcinoma

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