INFLUENCE OF D-1208I GENE POLYMORPHISM ON TISSUE FACTOR ACTIVITY

A.A. Petrov, A.V. Sepp, O.S. Petrova, N.N. Chartorizhskaya, N.N. Strambovskaya, Yu.A. Vitkovsky
State Budgetary Educational Institution of Higher Professional Education «Chita State Academy of Medicine» of the Ministry of Helthcare and Social Development of Russian Federation, Chita, Russia

reduced levels of monocytic TF expression in comparison with homozygous ones (160,1±53,0% and 198,6±72,9% M±SD, accordingly). If compared with homozygous allelic variants D-1208I heterozygous genotype is associated with less macrophagic TF expression in lungs (6,0 and 11,1 scores, correspondingly). The II genotype was accompanied with an increased concentration of TF in plasma only after LPS stimulation of whole blood. D-1208I mutation did not influence on TF procoagulant activity in plasma.
Keywords: 
D-1208I genetic polymorphism, tissue factor