ANALYSIS OF GENETIC POLYMORPHISMS IN ESTROGENMETABOLIZING ENZYMES IN OVARIAN CANCER PATIENTS IN THE SIBERIA REGION
Early diagnosis of ovarian cancer (OC) remains to be the actual problem in modern oncology due to the high mortality rate, asymptomatic
course of the disease in the early stages and its aggressiveness. The aim was to study the genetic polymorphism of pathogenetically significant estrogen
metabolizing enzymes to form risk groups for developing ovarian cancer.
With the use of PCR-RFLP method genetic polymorphism estrogen metabolizing enzymes metabolism (CYP1A1, CYP1A2, CYP19 and
SULT1A1) was analyzed in 96 women with ovarian cancer. As a comparison group 182 women without clinical signs of oncogynecological pathology
were selected. Females with the allele C, genotype A/C and C/C (ApaI polymorphism) of the gene CYP1A2 (OR=2,9, р
Keywords:
estrogen metabolizing enzymes, gene polymorphism, ovarian cancer