ASSOCIATIONS OF SINGLE NUCLEOTIDE POLYMORPHISMSWITH BONE TUMORS IN PATIENTS IN RUSSIAN POPULATION

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N.E. Kushlinskii (1), Yu.S. Timofeev (1), E.V. Generozov (2), V.A. Naumov (2), Yu.N. Soloviev (1), I.V. Boulytcheva (1)
1 - Federal State Budgetary Institution «The N.N. Blokhin Russian Cancer Research Center» of the Russian Academy of Medical Sciences, Moscow, Russian federation; 2 -Federal State Institution «Scientific Research Institute of Physicochemical medicine» of the Federal Medical – Biological Agency (FMBA) of Russia

Ethiology and pathogenesis of bone tumors presenting a rare group of oncological diseases, are not fully understood. We have studied 6 single nucleotide polymorphisms rs7921 (GH1), rs7956547(IGF1), rs3761243(GNRH2), rs11737764(FGF2), rs6599400(FGFR3), rs1690916(MDM2) associations with bone tumors in Russian patients. In our work we detect associations between 3 single nucleotide polymorphisms: IGF1.rs7956547, GNRH2.rs3761243 and FGFR3.rs6599400 in patients with bone tumors.
Keywords: 
bone tumors, single nucleotide polymorphisms