CONFIRMATION OF FIELD CANCERIZATION IN THE GENESIS OF SUPERFICIAL BLADDER CANCER
The paper presents the results of our own investigation of abnormal methylation of tumor suppressor genes RASSF1A, P16, CDH1,
LAMC3, DAPK in tumors and non-tumor tissues obtained from 64 patients with superficial bladder cancer. The purpose of the research is
to determine the participation of adjacent non-tumor tissue in the «field cancerization» in the genesis of urothelial carcinomas. We present
experimental evidence and analysis of the literature, confirming the possibility of urothelial carcinoma arising to the formation of the «field
cancerization», which is the consistent complex of the tumor and non-tumor tissue.
Keywords:
superficial bladder cancer, urothelial carcinomas, field cancerization, methylation of tumor suppressor genes