THE OBESITY: THE MOLECULAR MECHANISMS AND THE OPTIMIZATION OF TARGET THERAPY

 Download full text (PDF)

M.A. Paltsev (1), I.M. Kvetnoy (2), A.N. Ilnitski (3), K.I. Prashchayeu (3,4), T.V. Kvetnaia (5), G.N. Sovenko (3,4), V.I. Bessarabov (3)
1 -National Research Centre «Kurchatov Institute», Moscow, Russian Federation; 2 -The Research Institute of Obstetrics and Gynecology
named after D.O. Ott of the North-West Branch of the Russian Academy of Medical Sciences, St. Petersburg, Russian Federation;
3 -Independent Non-сommercial Organization «Researching Medical Center «Gerontology», Moscow, Russian Federation; 4 -National Researching University «Belgorod State University», Belgorod, Russian Federation; 5 -Saint Petersburg Institute of Bioregulation and Gerontology of the North-West Branch of the Russian Academy of Medical Sciences, St. Petersburg, Russian Federation

The article reviews modern data on the participation of signaling molecules in the pathogenesis of obesity. This review provides the detailed description of the functional morphology of adipose tissue as the major endocrine and immune organ. The imbalance in production of pro- and anti-inflammatory agents was shown to turn the adipose tissue into the medium maintaining chronic immune inflammation, pathogenetically connected with insulin resistance and metabolic syndrome, as well as cardiovascular and other disorders. Determination levels and monitoring dynamics of a number of signaling molecules levels in patients with obesity and concomitant somatic pathology can optimize the prescription of special targeted therapy for these conditions of polymorbidity. The possibility of delivery of new approaches to optimize the targeted therapy of obesity is considered from the point of view of the personalized medicine.
Keywords: 
obesity, signal molecules, neuroimmunoendocrinology, personalized medicine