MODIFICATION OF PROTEIN MOLECULES UNDER ENDOGENOUS INTOXICATIONAS A RISK FACTOR OF CHRONIC METABOLIC DISEASES

E.A. Yurieva (1), V.S. Sukhorukov (1), A.D. Tsaregorodtsev (1), E.S. Vozdvizhenskaya (1), M.N. Kharabadze (1), N.N. Novikova (2), M.V. Kovalchuk (2)
1 -Institute of pediatric and child surgery; 2 -National research center «Kurchatov institute»

The enhancement of ligand properties of protein molecules treated by toxic reagents has been revealed in model experiments in vitro on ordered protein films. In patients with endogenous intoxication caused by metabolic disorders there were also detected proteins with a high content of trace elements (Fe, Zn), that are excluded from the organism with urine as foreign compounds. In all such patients there were observed signs of chronic inflammatory processes. The presented results provide a basis of the following conception: the primary role in tissue damage resulted from the auto-aggression mechanism is played by modified proteins with accumulated trace elements (Fe, Zn), which aggravate the peroxide processes in tissues underlying chronic autoimmune inflammation. Such an approach explains the known in literature phenomenon of protein deposition (particularly low-density lipoproteins) and trace elements (Fe, Zn) in the inflamed blood vessels, kidneys and lungs in atherosclerosis.
Keywords: 
metabolic disorders, endogenous intoxication, urine microproteins, trace elements, autoimmune inflammation, atherosclerosis, total external reflection X-ray fluorescence analysis