SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY WITH 99MTc-MIBI AND 199Tl-CHLORIDEIN THE DIAGNOSIS AND EVALUATION OF THE EFFECTIVENESS OF CHEMOTHERAPY OF PRIMARYAND RECURRENT TUMORS OF THE LARYNXAND HYPOPHARYNX

aryngeal and laryngopharyngeal cancer response to neoadjuvant chemotherapy as well as to investigate the feasibility of 199Tl-chloride for visualization of primary and recurrent laryngeal tumors. Materials and Methods: The study included 60 patients with stage T1–4N0–1M0 laryngeal and laryngopharyngeal cancers and 5 patients with recurrent laryngeal cancer who were undergone both SPECT with 99mТс-MIBI at the stage of the primary diagnosis and after two courses of neoadjuvant chemotherapy and SPECT with 199Tl-chloride for visualization of primary and recurrent laryngeal tumors. Results: Sensitivity of SPECT with 99mТс-MIBI was found to be 97% and sensitivity of SPECT with 199Tl-chloride was 100%. Calculation of quantitative parameters showed that for 99mТс-MIBI the mean value of the tumor/mandibular glad/early index was 0,62±0,25, the mean value of the tumor/parotid gland/early index was 0,58±0,35 and the mean value of the tumor/scalp/early index was 5,64±3,52. For 199Tlchloride, the mean values of the tumor/mandibular gland/early index, tumor/parotid gland/early index and tumor/scalp/early index were 0,94±0,4, 1,10±0,6 and 4,69±3,06, respectively. Conclusion: This study has shown that SPECT with 99mТс-MIBI can be considered as not only the one of the additional methods in diagnosis of laryngeal and laryngopharyngeal cancers but also as a method of assessing the effect of neoadjuvant chemotherapy. Also, the present study has shown that 199Tl-chloride SPECT can be one of the auxiliary methods in detection of primary and recurrent laryngeal tumors.