RANK/RANKL/OPG SYSTEM IN BONE METASTASES AND PRIMARY BONE TUMORS
RANK/RANKL/OPG system – is a key element in bone homeostasis. In this review we depict the basic principles of functioning of this
system and known genetical anomalies affecting its components. Also we describe a number of pathological states associated with disorders in
RANK/RANKL/OPG system and consider the role of this system in development of bone metastases and in primary bone tumors.
Keywords:
RANK, RANKL, OPG, tumors, metastases, bones