ENDOMETRIUM: FROM NUCLEAR RECEPTORS TO TEST MODELS OF NEW DRUGS

E.K. Ailamazyan (1), G.H. Tolibova (1), M.A. Petrosyan (1), T.G. Tral' (1), S.V. Serdiukov (2)
1 -D.O. Ott Research Institute of Obstetrics and Gynecology, Mendeleyevskaya Line, 3, St. Petersburg, Russian Federation, 199034;
2 -Pasteur Research Institute of Epidemiology and Microbiology, Mira Str., 14, St. Peterburg, Russian Federation, 197101

Introduction. Endocrine factors are considered to be important in the etiology of spontaneous abortion. Aim of the study. Histological and immunohistochemical characterization of the expression of estrogen and progesterone receptors in the gravid endometrium during the first trimester of non-developing pregnancy under the treatment by progesterone analogues.Comparative experimental evaluation of gestagenic activity of micronized progesterone and didrogesterone on the animal model. Results. The study has revealed a decrease of the expression of progesterone receptors in the decidual tissue and an increase of the expression of estrogen receptors in the glands and decidual tissue. The receptor imbalance in case of polytherapy by analogues of progesterone has been found to be more prominent than that in case of monotherapy. Using an experimental animal model, it was revealed that both dydrogesterone and micronized progesterone can cause the secretory transformation of the endometrium, but dydrogesterone was found to be more efficient than micronized progesterone. Conclusion. Comparative experimental evaluation of gestagenic activity of micronized progesterone and didrogesterone has revealed the ability of both preparations to cause the secretory transformation of the endomentrium, however, pharmacological efficiency of didrogesterone was higher. Hormonal treatment of spontaneous abortion by progesterone analogues often does not have expected result that can be explained by excessive hormonal load leading to the endometrial receptor imbalance and inadequate tissue reaction to the hormonal therapy.
Keywords: 
non-developing pregnancy, estrogen and progesterone receptors, micronized progesterone, dydrogesterone, animal model, secretory transformation of the endometrium