COMPARATIVE ASSESSMENT OF GROWTH FACTORS EXPRESSION IN PIGMENT NEOPLASMS OF SKIN

Ye.M. Frantsiyants, Ye.F. Komarova,V.A. Bandovkina, V.V. Pozdnyakova, N.D. Cheryarina
Rostov Scientific and Research Institute of Oncology of the Ministry of Health of Russia,
14 line, 63, Rostov-on-Don, Russian Federation, 344037

Introduction. The study of growth factors in tissues of various kinds of nevi alongside with the skin melanoma can provide valuable information about the pathogenesis of the latter, determine the factors of early diagnostics of melanoma, as well as outline the ways of pathogenetically grounded therapy. The aim of the study. Studying the level of growth factors in cytosolic fraction of pigment nevi and skin melanoma tissues. Methods. The level of growth factors was studied by method of IFA in skin melanoma tissue samples (n=40) and nevi tissue samples (n=30), the factors being: vascular endothelial growth factor (VEGF) and its receptor (VEGF-R), epidermal grown factor (EGF) and its receptor (EGF-R), transforming one (TGF), fibroblasts growth factor (FGF), insulin-like growth factors 1 and 2 (IFR-1 and IFR-2). Results. It has been demonstrated that the tissue of nevi has particularities of metabolism distinguishing them both from melanoma tissue and from the intact skin tissue. So, the level of VEGF, EGF-R, TGF and IFR-2 in the tissue of nevi does not validly differ from the indicators in the intact skin, and the content of EGF, FGF, IFR-1 – from the indicators in the early stage melanoma tissue. Conclusions. The similarity of a number of indicators to those of early stage melanoma tissue gives grounds to suppose possible mechanisms of malignization of nevi.
Keywords: 
melanoma, nevus, growth factors