РОЛЬ АДИПОКИНОВ В ПАТОГЕНЕЗЕ ПЕРИНАТАЛЬНЫХ ОСЛОЖНЕНИЙ ПРИ НАРУШЕНИЯХ УГЛЕВОДНОГО ОБМЕНА У МАТЕРИ

DOI: https://doi.org/None

Р.В. Капустин (1), кандидат медицинских наук, О.Н. Аржанова (1, 2), доктор медицинских наук, профессор, С.А. Сельков (1), доктор медицинских наук, профессор, Пакин В.С. (1) 1-НИИ акушерства, гинекологии и репродуктологии им. Д.О. Отта, Российская Федерация, 199034, Санкт-Петербург, Менделеевская линия, д. 3; 2-Санкт-Петербургский государственный университет, медицинский факультет, Российская Федерация, 199034, Санкт-Петербург, Университетская наб., д. 7/9 E-mail: [email protected]

На основании анализа литературных данных оценена роль основных адипокинов (лептин, адипонектин, резистин, висфатин, апелин, оментин) в качестве значимых факторов развития неблагоприятных перинатальных осложнений при нарушениях углеводного обмена у матери. Показано, что ожирение и гипергликемия во время беременности приводят к нарушению синтеза и функции перечисленных цитокинов в жировой ткани. Дизрегуляция продукции изученных адипокинов вызывает нарушение функции β-клеток поджелудочной железы и инсулиновых рецепторов, что обусловливает развитие инсулинорезистентности и последующее формирование гестационного сахарного диабета. В условиях сопутствующего субклинического воспаления и оксидативного стресса происходят дальнейшие нарушения функции адипоцитов и макрофагов жировой ткани, а также выработка провоспалительных цитокинов, что приводит к формированию процессов эндотелиальной дисфункции и нарушению транспорта жирных кислот и аминокислот к плоду. Указанные патогенетические механизмы лежат в основе развития преэклампсии и макросомии плода. Показано, что нарушения регуляции продукции изученных адипокинов возникают уже на ранних сроках беременности. В связи с этим определение концентрации данных адипокинов может использоваться в рутинной практике с целью ранней диагностики и предупреждения нарушений углеводного обмена и гипертензивных расстройств во время беременности.
Ключевые слова: 
адипокины, лептин, адипонектин, резистин, висфатин
Для цитирования: 
Капустин Р.В., Аржанова О.Н., Сельков С.А., Пакин В.С. РОЛЬ АДИПОКИНОВ В ПАТОГЕНЕЗЕ ПЕРИНАТАЛЬНЫХ ОСЛОЖНЕНИЙ ПРИ НАРУШЕНИЯХ УГЛЕВОДНОГО ОБМЕНА У МАТЕРИ. Молекулярная медицина, 2017; (5): -

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