МЕХАНИЗМЫ ПОВРЕЖДАЮЩЕГО ДЕЙСТВИЯ ДЕКСТРАНСУЛЬФАТА НАТРИЯ В МОДЕЛИ ОСТРОГО ЯЗВЕННОГО КОЛИТА У МЫШЕЙ

DOI: https://doi.org/10.29296/24999490-2018-04-02

Т.И. Хомякова(1), кандидат медицинских наук, Н.А. Золотова(1), кандидат биологических наук, О.В. Макарова(1), доктор медицинских наук, профессор, Ю.Н. Хомяков(2), доктор биологических наук 1-ФГБНУ «Научно-исследовательский институт морфологии человека», Российская Федерация, 17418, Москва, ул. Цюрупы, д. 3; 2-ФКУЗ «Противочумный центр Роспотребнадзора», Российская Федеpация, 127490, Москва, ул. Мусоргского, д. 4 E-mail: [email protected]

Использование декстрансульфата натрия (ДСН) в экспериментальной биологии и медицине в качестве индуктора экспериментального язвенного колита считается валидизированной моделью для оценки эффективности фармакологических препаратов, разрабатываемых с целью лечения воспалительных заболеваний кишечника человека. В данном обзоре обобщены результаты исследований механизмов патогенеза острого колита у мышей, представленных в научных публикациях последних лет. Понимание этих механизмов позволит разрабатывать препараты направленного действия для профилактики и лечения острых воспалительных заболеваний у человека и проводить их доклиническую оценку на адекватной модели.
Ключевые слова: 
декстрансульфат натрия, острый колит, воспаление, эпителиальный барьер, микробиом
Для цитирования: 
Хомякова Т.И., Золотова Н.А., Макарова О.В., Хомяков Ю.Н. МЕХАНИЗМЫ ПОВРЕЖДАЮЩЕГО ДЕЙСТВИЯ ДЕКСТРАНСУЛЬФАТА НАТРИЯ В МОДЕЛИ ОСТРОГО ЯЗВЕННОГО КОЛИТА У МЫШЕЙ. Молекулярная медицина, 2018; (4): -https://doi.org/10.29296/24999490-2018-04-02
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