СИСТЕМА КРОВИ ПРИ ИНФИЦИРОВАНИИ COVID-19: ПАТОГЕНЕТИЧЕСКИЕ МЕХАНИЗМЫ НАРУШЕНИЙ И ПЕРСПЕКТИВЫ ТЕРАПИИ

DOI: https://doi.org/10.29296/24999490-2020-05-01

А.К. Мартусевич, доктор биологических наук ФГБОУ ВО «ПИМУ» Минздрава России, 603950, Российская Федерация, Нижний Новгород, пл. Минина, 10/1 E-mail: cryst-mart@yandex.ru

Целью данного обзора является системный анализ данных клинических наблюдений, международного опыта и обзоров, касающихся патогенетических аспектов влияния новой коронавирусной инфекции (КВИ) на систему крови. Поиск информации осуществлялся по базам MedLine, PubMed, РИНЦ. Приведена краткая характеристика этиологического агента с подробным анализом структуры данного вируса. Проанализированы особенности и механизмы иммунологических сдвигов, индуцированных SARS-CoV-2-инфицированием. Приведены и описаны гематологические и метаболические сдвиги в крови пациентов с COVID-19. С патогенетических и клинических позиций оценена реакция эритрона на развитие новой КВИ. Показано, что возбудитель новой КВИ оказывает многогранное негативное действие на систему крови пациентов, которое выражается в дисфункции иммунитета (преимущественно – клеточного) с формированием особого синдрома – «цитокинового шторма», гиперкоагуляции вплоть до развития синдрома диссеминированного внутрисосудистого свертывания, а также снижения абсолютного количества всех форменных элементов крови. Понимание механизмов развития данных сдвигов создает возможности для создания новых технологий таргентой терапии.
Ключевые слова: 
патогенез

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