THE STUDY OF THE ACUTE TOXICITY OF NEW RADIOPHARMACEUTICALS 99mTc-1-thio-D-glucose IN THE EXPERIMENT

DOI: https://doi.org/10.29296/24999490-2019-01-09

R.V. Zelchan(1), A.A. Medvedeva(1), O.D. Bragina(1), I.G. Sinilkin(1), V.I. Chernov(1, 2), E.S. Stasyuk(2), E.A. Tagirova(2), V.S. Skuridin(2) 1Tomsk National Research Medical Center, Kooperativny Street, 5, Tomsk, 634009, Russian Federation; 2National Research Tomsk Polytechnic University, Tomsk Polytechnic University, Lenina Avenue, 30, Tomsk, 634050, Russian Federation E-mail: [email protected]

The aim of the study. To investigate the overall acute toxicity of a new radiopharmaceutical in laboratory animals under the selected experimental conditions. Materials and methods. The study was performed on 80 white outbred rats (weight of males 220–260 g, the weight of females 180–240 g, aged of 10 weeks) and 80 white outbred mice (the weight of males 37–40 g, the weight of females 27–29 g, aged of 10 weeks). The studied drug was administered to the animals intravenously and intraperitoneally at three dose levels. Animal monitoring and the assessment of the toxic effect of the studied drug were carried out in strict accordance with the «Guidelines for preclinical drug research», edited by A.N. Mironov. Results. During the entire follow-up period after the administration of the drug, no animal death was observed. Also, no change was revealed in the behavior and in the reflex activity of animals. During the autopsy, there were no macroscopic changes in the main internal organs of the prepared animals. The results of the study showed the actual values of LD50 to be in the range of high doses and are not achievable under the selected experimental conditions. Сonclusion. The results of the presented study showed the safety of the use of the drug 99mTc-1-thio-D-glucose under the selected experimental conditions. According to the results of the study, the drug was classified as referred to a class of moderately toxic substances
Keywords: 
radiopharmaceutical, technetium-99m, glucose derivatives, oncology, acute toxicity

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