ACTUALITY AND PERSPECTIVES FOR THE PERSONALIZED APPROACH TO THE ALTERATION IN FUNCTIONAL ACTIVITY OF THE IMMUNE SYSTEM BASED ON MICRONUTRIENTS

DOI: https://doi.org/10.29296/24999490-2020-04-01

V.V. Yurasov(1), A.R. Sadykov(1), I.V. Zolkina(2), N.R. Khasbiullina(1), P.B. Glagovskiy3, I.S. Mamedov(4), M.A. Paltsev(1, 5) 1-Scientific and Laboratory Complex «Chromolab», Nauchnyi pr., 20/2, Moscow, 117246, Russian Federation; 2-The Research and Clinical Institute for Pediatrics named after Academician Yuri Veltischev of the Nikolay Pirogov Russian National Research Medical University, Ostrovityanova str. 1, Moscow, 117437, Russian Federation; 3-Research Institute of Cerebrovascular Pathology and Stroke of the Nikolay Pirogov Russian National Research Medical University, Ostrovityanova str. 1, Moscow, 117997, Russian Federation; 4-Center for the implementation of innovative medical and pharmaceutical technologies of the Nikolay Pirogov Russian National Research Medical University, Ostrovityanova str. 1, Moscow, 117997, Russian Federation; 5-Center For Immunology and Molecular Biomedicine of the Faculty of Biology of Lomonosov Moscow State University, Leninskie gory 1/12, Moscow, 119991, Russian Federatio

The review article discusses the principles of a personalized approach to changing the functional activity of the immune system based on micronutrients. The activity of the immune cells has been demonstrated to depend on the level of supplied not only macro- but also micronutrients – vitamins and minerals. Given the special needs of the immune system for micronutrients, an assessment of their adequate level is an important step in the development of the principles of personalized medicine. It is promising to measure the level of micronutrients using metabolome technologies. The article considers, the role and importance for the immune system functionality of the following micronutrients: fat-soluble vitamins – A, D, E, K, water-soluble vitamins – B1, B2, B3, B5, B6, B9, B12, vitamin C and trace elements – selenium, zinc, copper, magnesium, and manganese. The validity of the administration of micronutrients should be based on the analysis of the individual profile of these substances in the particular patient. A similar approach that underlies personalized medicine will not only increase both the efficacy and safety of preventive medical measures but also reduce the cost of expensive procedures, applying to target groups only. When considered as the most important direction in the development of clinical medicine personalized medicine can significantly improve the quality and the results of the treatment.
Keywords: 
personalized medicine, metabolomics, micronutrients, vitamins, microelements, immune system
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