FEATURES OF METABOLIC ATYPISM DURING THE DEVELOPMENT OF ONCOLOGICAL PATHOLOGY OF THE UROGENITAL SYSTEM

DOI: https://doi.org/10.29296/24999490-2021-01-04

T.V. Pavlova(1), N.B. Pilkevich(1), D.V. Bessmertnyy(2), I.A. Pavlov(2) 1-Belgorod State University, Pobedy st., 85, Belgorod, 308015, Russian Federation; 2-Belgorod Regional Oncological Dispensary, Kuibysheva st., 1, Belgorod, 308010, Russian Federation E-mail: [email protected]

Introduction. Urological and genital malignant neoplasms in men are an urgent problem. Every year, about 403.3 thousand newly diagnosed cases of kidney cancer and 34.5 thousand of penile cancer are registered in the world. With metabolic atypism, a change in all its components is observed, tumor cells trap the most important substrates and metabolites. The aim of the study. Study of the content of bioelements in certain types of cancer of the genitourinary system using innovative research methods. Methods. Patients with kidney and penile cancer were identified. For scanning electron microscopy, samples were taken without fixation, studied in an FE1 Quanta 600 FEG scanning microscope integrated with a detector for recording characteristic X-ray spectra from EPAX. Results. Along with tumor growth in the kidneys, the content of oxygen, magnesium, and calcium increases by 1.36, 2.45 and 2 times, respectively, and the content of sodium and potassium decreases by 1.2 and 5.25 times. In regional lymph nodes, the content of sodium increases by 1.2 times and phosphorus by 2.2 times, and oxygen, magnesium, potassium, and calcium decreases by 1.3, 2.2, 7.5, and 3.6 times respectively. In regional lymph nodes, the content of sodium increases by 1.2 times and phosphorus by 2.2 times, and oxygen, magnesium, potassium, and calcium decreases by 1.3, 2.2, 7.5, and 3.6 times respectively. Conclusion. With tumor growth in the kidneys, the content of oxygen, magnesium, calcium, and phosphorus increases, while the content of both sodium and potassium decreases. In the regional lymph nodes, the content of sodium and phosphorus increases, and there is a decrease in oxygen, magnesium, potassium, and calcium. In tumor growth in the penis, the content of oxygen, sodium, magnesium, phosphorus, calcium increases.
Keywords: 
malignant neoplasms, scanning electron microscopy, macroelements, genitourinary system
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