ANALYSIS OF GENETIC POLYMORPHISMS IN ESTROGENMETABOLIZING ENZYMES IN OVARIAN CANCER PATIENTS IN THE SIBERIA REGION

N.A. Afanasyeva (2,3), E.P. Khvostova (1), V.O. Pustyl’nyak (1,3), O.B. Chasovnikova (1), S.E. Krasil’nikov (2,3), L.F. Gulyaeva (1,3)
1 -Federal State Budgetary Institution «Research Institute for Molecular Biology and Biophysics of the Siberian Branch of the Russian Academy of Medical Sciences», Novosibirsk, Russian Federation; 2 -Federal State Budgetary Institution of Healthcare «Novosibirsk Regional Cancer Center» of the Novosibirsk region, Novosibirsk, Russian Federation; 3 -Federal State budgetary Institution of Higher professional education «Novosibirsk National Research State University», Novosibirsk, Russian Federation

Early diagnosis of ovarian cancer (OC) remains to be the actual problem in modern oncology due to the high mortality rate, asymptomatic course of the disease in the early stages and its aggressiveness. The aim was to study the genetic polymorphism of pathogenetically significant estrogen metabolizing enzymes to form risk groups for developing ovarian cancer. With the use of PCR-RFLP method genetic polymorphism estrogen metabolizing enzymes metabolism (CYP1A1, CYP1A2, CYP19 and SULT1A1) was analyzed in 96 women with ovarian cancer. As a comparison group 182 women without clinical signs of oncogynecological pathology were selected. Females with the allele C, genotype A/C and C/C (ApaI polymorphism) of the gene CYP1A2 (OR=2,9, р
Keywords: 
estrogen metabolizing enzymes, gene polymorphism, ovarian cancer