DETERMINATION OF DONOR SPECIFIC HLA ANTIBODIES IN THE EARLY POST-TRANSPLANT PERIOD
To assess the detection and prognostic significance of donor-specific HLA antibodies serum samples from 66 recipients were examined.
Donor-specific antibodies (DSA) have been identified in the sera of 15 patients (22,7%). To assess the effect on DSA during the early posttransplant
period, the results of treatment of 38 renal transplant recipients have been analyzed. that donor-specific HLA antibodies were
found to be accompanied by the development of rejection in 5 out of 8 recipients, that in two cases led to the loss of the graft. Among the 30
patients in whom no DSA were found, the graft rejection was diagnosed in 4 cases. The acute cellular rejection was recorded in three patients.
Thus, de novo generation of donor-specific HLA antibodies is a poor prognostic factor in terms of rejection and graft loss.
Keywords:
HLA-antibodies, donor-specific antibodies (DSA), rejection crises, organ transplantation