Val66Met BDNF POLYMORPHISM IN PATIENTS WITH A HIGH RISKOF MORTALITY DUE TO STROKE AND SEVERE TRAUMATIC BRAIN INJURY
We have studied BDNF gene Val66Met polymorphism in patients with a high risk of mortality due to stroke or severe head injury.
Genotype ValVal rate was higher than that of in the control group in the total sample of subjects (75,5% and 63,6%; χ2=4,63; df=1; p=0,03).
In patients with consequences of severe head injury Val allele frequency was 90,0%, in patients with hemorrhagic stroke – 87,1%, in cases
with ischemic stroke – 85,4%, in the united group of stroke patients, compared with controls, the differences were close to be significant
(χ2=3,67; df=1; p=0,055). In this united group detected differences in frequency of genotypes were similar to controls (χ2=3,88; df=1;
p=0,049). In genotype Met– cases the average size of the lesion of the brain as a result of ischemic stroke was 79,01cm3, Met+ – 108,85
(p=0,13). Val allele of Val66met BDNF polymorphism may be a factor of survival in patients with ischemic and hemorrhagic stroke and
severe traumatic brain injury.
Keywords:
stroke, traumatic brain injury, genes, brain-derived neurotrophic factor