INCULIN-LIKE GROWTH FACTORS IN THE SERUM OF BREAST CANCER PATIENTS
Introduction. Breast cancer pathogenesis is associated with alterations in processes of regulating of IGF effects and also in IGF-signaling
pathway activation. The direct correlation between high IGF blood serum levels and the rescue of malignancies in prostate, breast, ovarium,
colon, lung and cervix.
The aim of the study. Evaluation of IGF-I and IGF-II blood serum levels in breast cancer patients and in practically healthy women,
and also analysis of links between obtained data and basic clinico-morphological characteristics of breast cancer.
Methods. Insulin-like growth factors 1 and 2 (IGF 1 and IGF 2) were measured in blood serum of 79 patients with primary breast cancer
and 16 control practically healthy women aged 27–76 using standard ELISA kits («IGF-I ELISA», «IGF-II ELISA» (Mediagnost GmbH,
Germany). HER2/neu, ER and PR receptor status of breast cancer tissues was evaluated by standart immunohistochemical methods.
Results. No correlation was found between basic IGF-I and IGF-II serum levels and TNM rates. The IGF serum levels correlated
reliably only with menopausal status and with (ER)(PR)Her-2/neu status of breast cancer.
Conclusions. Obtained data confirm hypothesis about involvement of IGF-signaling pathway in regulation of receptor-negative breast
cancer growth.
Keywords:
IGF 1, IGF 2, breast cancer