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IMPORTANCE OF HEAT SHOCK PROTEINS 70 KDA IN DEVELOPMENT OF ACUTE FOCAL MYOCARDIAL AND CEREBRAL ISCHEMIA
DOI: https://doi.org/None
In acute focal ischemia of the heart and brain similar processes are developing despite the obvious differences in the structure, function, and blood supply of these organs. It was shown that under ischemic conditions synthesis stress induced proteins including heat shock proteins (HSP) increased dramatically independently of the cell type and their localization. This review presents a contemporary view of involvement of HSP in the process of ischemic injury. The main types of these proteins, their receptors, mechanisms of HSP functioning and the sources of circulating Hsp70 are described. The data of experimental and clinical studies on the role of HSP70 in patients with atherosclerosis, and their importance in the development of acute myocardial ischemia and focal cerebral ischemia are summarised. The possible reasons of similarity of the effect of HSP in ischemic lesions in different vascular beds are discussed. Cardioprotectiv and neuroprotectiv properties of HSP70 connected with chaperone, anti-apoptotic and immunomodulatory activity of the protein are described. The reviewed data allow consider HSP70 as a «target» for the development of new effective approaches to prevention and treatment of cardiovascular diseases.
Keywords:
heat shock proteins, ischemic stroke, myocardial infarction, atherosclerosis
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