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DBH GENE POLYMORPHISM IN PSORIASIS PATIENTS
DOI: https://doi.org/10.29296/24999490-2019-04-09
Introduction. Psoriasis is a chronic inflammatory autoimmune disease with complex etiology including inheritable factors as well. Some scientists suggest psoriasis to be a systemic disease affecting not only skin. Thus, on the edge of dermatology and psychiatry, there is formed a new scientific field called psychodermatology, which highlights the nature of the link between skin diseases and mental disorders. The aim of the study is to evaluate the role of 3 polymorphic loci in the dopamine beta-hydroxylase (DBH) gene (rs141116007, rs2097629, and rs1611115) in the development of psoriasis. Methods. Genotypes were studied with PCR-RFLP method. Restriction products were separated in 2% agarose gene. Statistical analysis was performed in WinPepi and in APSampler software. Results. We discovered an association of rs1611115:T allele with psoriasis. This allele has a recessive model of inheritance – the presence of C allele reduces risk of psoriasis by 4 times. Complex genotype study revealed an association between rs1611115:TT genotype with psoriasis: p
Keywords:
psoriasis, psychodermatology, DBH, rs141116007, rs2097629, rs1611115, association studies
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