ГОРМОН АДРОПИН: ВЛИЯНИЕ НА ЗАБОЛЕВАНИЯ, АССОЦИИРОВАННЫЕ С ВОЗРАСТОМ

DOI: https://doi.org/10.29296/24999490-2021-02-03

Б.И. Кузник(1, 2), Н.И. Чалисова(3, 4) 1-ФГБОУ ВО «Читинская государственная медицинская академия», Российская Федерация, 672090, Чита, ул. Горького, 39а; 2-Инновационная клиника «Академия здоровья», Российская Федерация, 672000, Чита, ул. Кохановского, 13; 3-ФГБУН «Институт физиологии им. И.П. Павлова» РАН, Российская Федерация, 199034, Санкт-Петербург, наб. Макарова, д. 6; 4-АНО ВО НИЦ «Санкт-Петербургский институт биорегуляции и геронтологии», Российская Федеpация, Санкт-Петербург, 197110, пр. Динамо, д. 3 E-mail: ni_chalisova@mail.ru

В обзоре приведены сведения о гормоне пептидной природы – адропине, близкому по свойствам к ирисину. Адропин относится к миокинам и экспрессируется в центральной нервной системе (ЦНС), печени, почках, сердце, поджелудочной железе, тонкой кишке, эндотелиальных клетках. Адропин регулирует энергетический баланс, метаболизм глюкозы и жирных кислот. Содержание адропина в различных органах и тканях снижается с возрастом, тогда как при физической нагрузке его концентрация в крови возрастает. Адропин играет существенную роль в ЦНС. При нейродегенеративных заболеваниях ЦНС содержание адропина в крови и тканях головного мозга снижается. В экспериментах на животных показано, что адропин способствует снижению дегенеративных изменений в ЦНС. При заболеваниях сердечно-сосудистой системы, сахарном диабете, метаболическом синдроме, раке молочной железы и эндометрия, синдроме поликистозных яичников концентрации адропина в крови снижается. Выявлена отрицательная корреляция между содержанием адропина, уровнем кровяного давления, концентрацией эндотелина и резистентностью к инсулину, и положительные связи – с кардиальным тропонином и натрийуретическим пептидом. Можно полагать, что адропин играет существенную роль в развитии заболеваний, ассоциированных с возрастом
Ключевые слова: 
сердечно-сосудистая система, сахарный диабет, метаболический синдром, онкологические заболевания, старение

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