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ГЕНЫ МОНОРЕЗИСТЕНТНОСТИ КАК МАРКЕР ДЛЯ ПЕРСОНАЛИЗАЦИИ ХИМИОТЕРАПИИ РАКА ЛЕГКОГО
DOI: https://doi.org/10.29296/24999490-2018-01-01
Результаты хирургического лечения рака легкого (РЛ) II–III стадии остаются неудовлетворительными, а используемая химиотерапия не дает существенного прироста выживаемости больных. Это объясняется недостаточно эффективным подбором химиопрепаратов и тактики лечения конкретного больного, основанной только на использовании стандартных клинических параметров. Существенная роль в формировании устойчивости опухоли легкого к назначаемым химиопрепаратам принадлежит генам монорезистентности, которые определяют резистентность/чувствительность опухолевых клеток к отдельным химиопрепаратам. В представленном обзоре рассмотрены механизмы транспорта, активации и мишени химиопрепаратов, а также определяются основные маркеры для прогнозирования их эффективности, и возможность применения их в клинической практике. Для РЛ охарактеризованы такие гены монорезистентности, как АВСС5, RRM1, ERCC1, TOP1, TOP2a, TUBB3 и TYMS. Приведены клинические исследования, доказывающие эффективность их использования в качестве предиктивных маркеров для назначения отдельных химиопрепаратов. Приводится проспективное исследование авторов статьи с персонализированным назначением адъювантной химиотерапии больным РЛ.
Ключевые слова:
рак легкого, химиотерапия, гены монорезистентности, химиочувствительность
Для цитирования:
Цыганов М.М., Дерюшева И.В., Родионов Е.О., Ибрагимова М.К., Миллер С.В., Литвяков Н.В. ГЕНЫ МОНОРЕЗИСТЕНТНОСТИ КАК МАРКЕР ДЛЯ ПЕРСОНАЛИЗАЦИИ ХИМИОТЕРАПИИ РАКА ЛЕГКОГО. Молекулярная медицина, 2018; (1): -https://doi.org/10.29296/24999490-2018-01-01
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