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HPgV-ИНФЕКЦИЯ
DOI: https://doi.org/10.29296/24999490-2021-06-03
Цель: анализ данных литературы по HPgV-инфекции, вызываемой вирусом Human pegivirus-1 (ранее гепатит G, HGV, GBV-C). Материал и методы: поиск, по ключевым словам, публикаций в базах данных Scopus, PubMed и Elibrary за период с 1995 по 2020 г. Результаты: описана история изучения вируса, его строение, генетическая гетрогенность, а также проблема эпидемиологии, тропизма и патогенеза данной инфекции. В связи с наличием ряда свойств вируса отражены возможные перспективы исследования HPgV-инфекции для популяционной генетики и генной терапии. Представлены современные данные о связи HPgV-инфекции с ВИЧ-инфекцией, лимфомами и некоторыми другими заболеваниями. Дана краткая характеристика относительно недавно описанного вируса 2-го типа (HPgV-2). Обозначены проблемы диагностики и интерпретации HPgV-инфекции в Российской Федерации и зарубежных странах. Заключение: несмотря на то, что изначально возбудитель HPgV-инфекции был описан как причина развития гепатита, он не является цитопатическим вирусом, а заражение не связано с развитием патологических процессов.
Для цитирования:
Литвинов В.В., Фрейнд Г.Г., Коробов В.П., Шестакова А.Д. HPgV-ИНФЕКЦИЯ. Молекулярная медицина, 2021; (6): -https://doi.org/10.29296/24999490-2021-06-03
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