CAV1 GENE POLYMORPHISM IN PATIENTS WITH PRIMARY OPEN-ANGLE GLAUCOMA

DOI: https://doi.org/None

N.A. Logunov, Y.A. Vitkovsky Chita State Medical Academy, Gorkogo str., 39A, Chita, 672007, Russian Federation

Introduction. Glaucoma is associated with a progressive decrease of visual functions, leading to blindness. One of the important factors is the outflow of the ocular fluid. А genetic association study has identified a sequence variant at the chromosome 7q31 (rs4236601) near kaveolin genes in patients with openangle glaucoma. Kaveolins participate in the active vesicular transport, many cellular processes, signal transfer and migration. Aim. To study the polymorphism of the gene of caveolin 1 (CAV 1) both in healthy persons and glaucoma patients residing in theTransbaikalian region. Methods. CAV1 gene polymorphism (G2891A) was determined by polymerase chain reaction. The amplification products were evaluated by using electrophoresis. Results. The estimation of distribution of allelic variants of caveolin-1 gene in 147 patients with primary open-angle glaucoma and 214 healthy persons was performed. The occurrence of G allele (G2891A) in patients with glaucoma was identified more often than in healthy persons (χ2=5,65; p
Keywords: 
primary open-angle glaucoma, caveolin-1, genetic markers
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