KISSPEPTIN AND KISSPEPTIN RECEPTOR’S EXPRESSION IN EXTERNAL GENITAL ENDOMETRIOSIS

DOI: https://doi.org/None

A.O. Drobintseva, T.S. Kleimenova, V.O. Polyakova D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya line, 3, Saint-Petersburg, 199034, Russian Federation

Introduction. Kisspeptin, was originally identified as a protein suppressing metastasis, since it has the ability to inhibit the migration of melanoma cells. It was established that KISS1 / KISS1R has a significant impact on the process of puberty and regulates the reproductive function of the body. There are no studies that determine the role of this system in the EGE. Aim of the study. Rate expression of system kisspeptin (KISS1) and kisspeptin receptor (KISS1R) for external genital endometriosis (EGE) in endometrial tissue and endometrial heterotopias. Methods. For immunohistochemical study biopsis was taken from 30 patients with IEG II and III degree, the control group consisted of 15 patients, in which the endometrial pathology was excluded. Results. Immunohistochemical study of the endometrium and heterotopias found that KISS1/KISS1R expressed in patients and in the control group, but with different intensity. Conclusion. Further study of KISS1/KISS1R expression in endometrial tissue in normal and pathological conditions may be a promise for the development of new methods of molecular diagnostics and targeted therapy of gynecological diseases.
Keywords: 
kisspeptins, kisppeptin receptor, external genital endometriosis, immunohistochemistry
Список литературы: 
  1. Strizhakov A.H., Davydov A.I. E`ndometrioz. Klinicheskie i Teoreticheskie aspekty. Medicina. 1996; 8–11.[Strizhakov A.H., Davydov A.I. Endome-triosis. Clinical and Theoretical Aspects. Medicina. 1996; 8–11 (in Russian)]
  2. Adamyan L.V., Gasparyan S.A. Genital`nyy e`ndometrioz. Sovremennyy vzglyad na problemu. 2004; 15–8.[Adamjan L.V., Gasparjan S.A. Genital endometriosis. Sovremennyj vzgljad na problemu. 2004; 15–8 (in Russian)]
  3. Pechenikova V.A., Kostyuchek D.F., Kvetnoy I.M. Molekulyarnye aspekty izucheniya pato- i morfogeneza genital`nogo e`ndometrioza. Molekulyarnaya medicina. 2008; 1: 3–5.[Pechenikova V.A., Kostjuchek D.F., Kvetnoj I.M. Molecular aspects of the study of patho- and morphogenesis of genital endometriosis. Molekulyarnaya Meditsina. 2008; 1: 3–5 (in Russian)]
  4. Molotkov A.S., Yarmolinskaya M.I., Polyakova V.O. Znachenie e`kspressii aromatazy v patogeneze naruzhnogo genital`nogo e`ndometrioza. Molekulyarnaya medicina. 2012; 4: 41–4.[Molotkov A.S., Jarmolinskaja M.I., Polja-kova V.O. Significance the expression of aromatase in the pathogenesis of external genital endometriosis. Molekulyarnaya Meditsina. 2012; 4: 41–44 (in Russian)]
  5. Yarmolinskaya M.I., Tarasova M.A., Sel`-kov S.A. Naruzhnyy genital`nyy e`ndome-trioz; posobie dlya vrachey. 2010; 84.[Jarmolinskaja M.I., Tarasova M.A., Sel’kov S.A. External genital endometriosis; Guide for Doctors. 2010; 84 (in Russian)]
  6. Makri A., Msaouel P., Petraki C. KISS1/KISS1R expression in eutopic and ectopic endometrium of women suffering from endometriosis. In vivo. 2012; 26 (1): 119–27.
  7. Qiao C., Wang C.H., Shang T. Clinical significance of kiss- 1 and matrix metal-loproteinase-9 expression in trophoblasts of women with preeclampsia and their relation to perinatal outcome in neonates. Zhonghua Fu Chan Ke Za Zhi. 2005; 40: 585–90.
  8. Takino T., Koshikawa N., Miyamori H. Cleavage of metastasis suppressor gene product KISS1 protein/metastin by matrix metalloproteinase. Oncogene. 2003; 22: 4617–26
  9. Roman A.C., Pinto M., Almeida T.A. Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract. 2012; 7: 4–6.
  10. Messager S., Chatzidaki E.E., Ma D. Kisspep-tin directly stimulates gonadotropin-releasing hormone release via G-protein coupled receptors 54. Tr. Natl. Acad. Sci. USA. 2005; 102 (5): 1761–6.
  11. d’Anglemont de Tassigny X., Colledge W. The role of kisspeptin signaling in reproduc-tion. Physiology. 2010; 25: 207–17.
  12. Sudalina M.N., Durnova A.O., Polyakova V.O., Pal`ceva E.M. Svyaz` kisspeptinov s opuholeobrazovaniem v zhenskoy reproduktivnoy sisteme. Molekulyarnaya medicina. 2015; 5: 19–23.[Sudalina M.N., Durnova A.O., Poljakova V.O. Association of kisspeptins with tumoro-genesis in the female reproductive system. Molekulyarnaya Meditsina. 2015; 5: 19–23 (in Russian)]