G276T ADIPONECTIN GENE POLYMORPHISM IN DEVELOPMENT OF OBESITY AND OBESITY-RELATED DISEASES IN KYRGYZ POPULATION

DOI: https://doi.org/None

Zh.T. Isakova (1), E.T. Talaibekova (1), D.A. Asambaeva (1), A.S. Kerimkulova (2), O.S. Lunegova (2), A.A. Aldashev (1) 1 -Institute of Molecular Biology and Medicine, Togolok-Moldo str, 3, Bishkek, 720040, Kyrgyz Republic; 2 -National Center of Cardiology and Internal Medicine, Togolok-Moldo str, 3, Bishkek, 720040, Kyrgyz Republic

The aim of this work was to study the relationship between adiponectin gene polymorphisms G276T with obesity and obesity-related diseases in the Kyrgyz population. Material and methods. We genotyped 288 Kyrgyz subjects (143 women and 145 men; age range: 30–75 years). Arterial blood pressure, anthropometric measurement and fasting blood glucose, lipid profiles were measured in every case. The Adiponectin gene polymorphism (G276T) was analyzed by standard method with the use of PCR- RFLP. Results. Among Kyrgyz 288 subjects the allele frequencies were 0,75 for G allele and 0,25 for T allele in G276T of the adiponectin gene (ADIPOQ). Genotypes distributions of G276T polymorphisms were no significantly different between obese (BMI>30 kg/m2) and nonobese cases (BMI
Keywords: 
polymorphism G276T, adiponectin gene, obesity, diabetes mellitus type 2, Kyrgyz population
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