DEVELOPMENTAL CHANGES OF THE EXPRESSION OF CALCIUM-BINDING PROTEINS IN AUTONOMIC GANGLIONIC NEURONS

DOI: https://doi.org/None

Masliukov P.M., Nozdrachev A.D., Emanuilov A.I.

Calbindin 28 kDa, calretinin and parvalbumin are referred to calcium-binding proteins which are both widely distributed in the nervous system and selectively expressed in certain population of neurons. These proteins are expressed not only in the central nervous system, but also in the autonomic ganglia. Calbindin and parvalbumin are found in sympathetic ganglia of rodents, calbindin and calretinin are found in metasympathetic intramural ganglia. Their functions are poor understood but one can suggest their important role in the regulation of theCa2+ load of the cell. Сalcium-binding proteins also play an important role in the development of autonomic neurons. There is an increasing of the percentage of сalbindin and calretinin in the metasympathetic intramural ganglia of small intestine in the early postnatal development, whereas in sympathetic ganglia the percentage of calbindin is lower. Possibly, the functional importance of such changes can be explained by the role of calcium currents in the development of neurons and the synaptic transmission.
Keywords: 
сalbindin, calretinin, parvalbumin, autonomic ganglia
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