STUDYING THE RELATIONSHIP OF IRON CONCENTRATION IN BLOOD SERUM WITH FERRITIN, TRANSFERRIN AND OTHER CHEMICAL ELEMENTS

DOI: https://doi.org/10.29296/24999490-2023-02-07

G.D. Morozova(1, 2), A.R. Sadykov(3), A.A. Logvinenko(4), E.D. Namiot(1), V.V. Yurasov(3), A.V. Skalny(1, 5)
1-I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya str. 8/2, Moscow, 119991, Russian Federation;
2-Golikov Research Center of Toxicology, Bekhtereva str. 1, St. Petersburg, 192019, Russian Federation;
3-Laboratory of metabolomic diagnostics, Starokaluzhskoe sh. 63, Moscow, 117630, Russian Federation;
4-Private healthcare institution «Central clinical hospital «RZD-Medicine», Volokolamskoe sh., 84, Moscow, 125367, Russian Federation;
5-Peoples Friendship University of Russia, Mikluho-Maklaya str. 6, Moscow, 117198, Russian Federation

Introduction. Iron is an essential component of key metabolic processes in the body. Transferrin and ferritin are the main compounds that affect serum iron levels. For a competent diagnosis of iron metabolism disorders, knowledge of the principles of various analytical techniques is necessary. It is necessary to consider the interactions between iron and other chemical elements that affect the metabolism of iron in the body. The aim of the study. The aim of the study was to study the relationship between the iron concentration measured by the standard method and the ICP-MS method, with the indicators of ferritin and transferrin in blood serum; study of correlations of iron with other elements in blood serum. Material and methods. The study was conducted using a database of laboratory tests. In the blood serum of the examined, ferritin, transferrin, iron were measured by the ICP-MS method, the iron colorimetric method (6786, 1809, 13161, 10073 laboratory tests, respectively), as well as other chemical elements by the ICP-MS method. The relationship between the indicators was assessed using the Spearman rank correlation coefficient. Results. It was shown that the traditionally accepted relationships between the concentrations of iron and ferritin, transferrin are not manifested in the entire range of concentrations of these proteins. At different concentrations of transferrin and ferritin, certain patterns of changes in the concentration of serum iron in men and women were revealed. Statistically significant correlations of iron concentrations in blood serum with zinc, vanadium, selenium, nickel, manganese, magnesium, potassium, iodine, copper, chromium, cobalt, cadmium were determined. Conclusion. On a large sample the relationship of iron concentrations in blood serum with ferritin, transferrin, and other chemical elements was studied. It is necessary to evaluate the results of measurements of iron metabolism, taking into account the gender of the subject and the presence of interelement interactions.
Keywords: 
iron, ferritin, transferrin, trace elements, blood serum, ICP-MS
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