P.A. Podlesnaya, O.V. Kovaleva, A.A. Petrenko, N.E. Kushlinskii, A.N. Gratchev
FSBI National Medical Research Center of Oncology named after N.N. Blokhin» Ministry of Health of Russia,
Kashirskoe highway, 24, Moscow, 115522, Russian Federation

This review is devoted to summarizing the available data on the expression of long non-coding RNAs (lncRNAs) in lung cancer cells and tissues, their role in tumorigenesis, association with clinical and morphological characteristics and disease prognosis. The purpose of this study is to search and describe new lncRNAs involved in the mechanisms of lung cancer progression. Material and methods. An analysis of scientific literature was carried out using the PubMed/Medline, RSCI/elibrary databases over the past 5 years. Results. Long non-coding RNAs are a promising tool for the diagnosis and treatment of cancer, including lung cancer. To date, a large number of lncRNAs have been described that are associated with lung cancer and/or involved in various mechanisms of disease progression. However, data on the role of each of them is fragmentary and further comprehensive studies of the functions of the identified lncRNAs in the pathogenesis of lung cancer are required.
long non-coding RNAs, lncRNAs, tumor, lung cancer, carcinogenesis, resistance, antitumor immunity

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