T.S. Zubareva(1, 3), V.E. Koroleva(2), A.S. Zubareva(1, 3), Yu.S. Krylova(1, 4), E.S. Mironova(1, 3), P.K. Yablonsky(1)
1-FGBU “St. Petersburg Research Institute of Phthisiopulmonology” of the Ministry of Health of the Russian Federation,
Ligovsky Prospekt, 2–4, St. Petersburg, 191036, Russian Federation;
2-Federal State Autonomous Educational Institution of Higher Education «Peter the Great St. Petersburg Polytechnic University»,
st. Politekhnicheskaya, 29, St. Petersburg, 195251, Russian Federation;
3-ANO Scientific Research Center «St. Petersburg Institute of Bioregulation and Gerontology»,
Dynamo Ave., 3, St. Petersburg, 197110, Russian Federation;
4-Federal State Budgetary Educational Institution of Higher Education “First St. Petersburg State
Medical University named after. acad. I.P. Pavlova» Ministry of Health of the Russian Federation,
st. Lev Tolstoy, 6–8, St. Petersburg, 197022, Russian Federation

Relevance. The review is devoted to the analysis of modern ideas about the functional role of connexins in intercellular interactions, their participation in maintaining cellular and tissue homeostasis and in the pathogenesis of diseases of the respiratory system. The possibility of considering connexins as potential targets for targeted therapy is discussed. The purpose of the study was to consider possible molecular mechanisms of intercellular interactions through gap channels formed by connexins and ways to regulate their work. Material and methods: analysis and systematization of scientific literature over the past 15 years was carried out in the PubMed, Scopus and Google Scholar databases. Results. Particular attention in the review is paid to the participation of connexins in gap junctions and hemichannels in the processes of transport of calcium ions, metabolite molecules, ATP and mitochondria across the cell membrane. Disturbances in the regulation of these processes of intercellular interactions make a significant contribution to the pathogenesis of many diseases, in particular diseases of the respiratory system. Deepening the understanding of the molecular mechanisms of the work of various connexins in gap channels will provide an opportunity for the promising development of therapeutic approaches using blocking or stimulating the activity of a specific connexin, taking into account its critical functions in the implementation of intercellular interactions in general.
connexin, Cx43, Cx37, connexon, gap junction, intercellular interactions, signaling molecules, diseases of the respiratory system, targeted therapy

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