MOLECULAR BASES OF THE FEEDING BEHAVIOR CONTROL

DOI: https://doi.org/None

K.A. Matosyan, D.A. Pustovalov, A.N. Oranskaya, A.M. Mkrtumyan, K.G. Gurevich Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Delegatskaya street, 20/1, Moscow, Russian Federation, 127473

Since the middle of the last century, discoveries in the area of molecular biology and physiology somehow led to the revolution in the view of the function and role of the adipocyte in the human body. To date, there have been known and studied more than four adipokines. For the present time their functions are known to be diversified and include the regulation of feeding behavior, carbohydrate metabolism, atherosclerosis, thrombogenesis and so on. Receptors for these molecules are localized as well in peripheral organs, as in organs of the central nervous system (CNS), namely in hypothalamic nuclei. At the level of the central nervous system there is the interaction between adipokines and hormones which regulate feeding behavior. Until recently, only serotonin and neuropeptide Y were referred to them. A similar effect of ghrelin molecules and nesfatin-1 was discovered less than five years ago. The presented review includes the latest data on the structure and function of these molecules, as well as recent data of international surveys about international investigations on their mutual influence.
Keywords: 
adipokines, nesfatin-1, ghrelin, feeding behavior, puberty
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